Day: February 13, 2023

Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass was written by Uju;Goto, Masahiro;Kamiya, Noriho. And the article was included in Bioresource Technology in 2016.Category: pyridine-derivatives This article mentions the following:

The aim of this work was to design a new method for the efficient saccharification of lignocellulosic biomass (LB) using a combination of peracetic acid (PAA) pretreatment with ionic liquid (IL)-HCl hydrolysis. The pretreatment of LBs with PAA disrupted the lignin fractions, enhanced the dissolution of LB and led to a significant increase in the initial rate of the IL-HCl hydrolysis. The pretreatment of Bagasse with PAA prior to its 1-butyl-3-methylimidazolium chloride ([Bmim][Cl])-HCl hydrolysis, led to an improvement in the cellulose conversion from 20% to 70% in 1.5 h. Interestingly, the 1-butyl-3-methylpyridium chloride ([Bmpy][Cl])-HCl hydrolysis of Bagasse gave a cellulose conversion greater than 80%, with or without the PAA pretreatment. For LB derived from seaweed waste, the cellulose conversion reached 98% in 1 h. The strong hydrolysis power of [Bmpy][Cl] was attributed to its ability to transform cellulose I to II, and lowering the d.p. of cellulose. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Category: pyridine-derivatives).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cyclometalated Iron and Ruthenium Complexes Supported by a Tetradentate Ligand Scaffold with Mixed O, N, and C Donor Atoms: Synthesis, Structures, and Excited-State Properties was written by Law, Kwok-Chung;Tang, Zhou;Wu, Liangliang;Wan, Qingyun;To, Wai-Pong;Chang, Xiaoyong;Low, Kam-Hung;Liu, Yungen;Che, Chi-Ming. And the article was included in Organometallics in 2022.Name: Pyridinehydrochloride This article mentions the following:

Cyclometalated Fe(II/III) and Ru(II/III) complexes bearing a tetradentate dianionic [O-N-C-N] ligand (H₂[O-N-C-N] = 2-(6-(3-(pyridin-2-yl)phenyl)pyridin-2-yl)phenol) were synthesized and structurally characterized. The strong-field dianionic [O-N-C-N] ligand enforces all of these complexes in low-spin state at 298 K as revealed by ¹H NMR, magnetic susceptibility, and EPR measurements. A 77 K 2-MeTHF glassy solution of the bis(arylisocyanide) Ru(II) complex [Ru^II(O-N-C-N)(XylNC)₂] displays a weak and broad emission band (浣?sub>em: 680 nm; 锜? 0.27娓璼) while the others are nonemissive. DFT/TDDFT calculations revealed that ¹dd excited states of the d⁶ [M(II)(O-N-C-N)(PMe₃)₂] (M = Fe, Ru) are strongly destabilized. The [Fe(II)(O-N-C-N)(PMe₃)₂] exhibits panchromatic absorption up to 850 nm. A combined study of fs-TA, spectroelectrochem., and theor. calculation revealed that the possible ³MLCT excited state (锜? 14 ps) of [Fe(II)(O-N-C-N)(PMe₃)₂] decays via a lower-lying ³dd excited state. For the d⁵ [M(III)(O-N-C-N)(PMe₃)₂]⁺ (M = Fe, Ru), the presence of low-lying ²dd excited states and ²LMCT states with short lifetimes (锜? 11.7-12.6 ps) is suggested. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. VI. Further studies on the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with phenyl isocyanates was written by Harano, Kazunobu;Suematsu, Fumihiro;Matsuoka, Toshikazu;Hisano, Takuzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Related Products of 3718-65-8 This article mentions the following:

To provide addnl. evidence for the concerted mechanism postulated for the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with Ph isocyanates, kinetic studies on the cycloaddition reactions were conducted in a variety of solvents. The cycloaddition showed low sensitivity to the ionizing power of the medium, indicating that it proceeds by a mechanism which involves very little change in charge separation between the ground state and the transition state. The observed cycloadditivity and site selectivity are discussed in terms of the following controlling factors based on MINDO/3 calculations: HOMO-LUMO control, secondary orbital interaction, steric interaction, dipole-dipole interaction, and charge-transfer complexation. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Related Products of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. XVI. Cycloaddition behavior of aromatic N-oxides toward electron-deficient allenes and x-ray structure of the 1,4-dipolar cycloadduct was written by Hisano, Takuzo;Harano, Kazunobu;Matsuoka, Toshikazu;Matsuzaki, Tatsuya;Eto, Masashi. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Computed Properties of C7H9NO This article mentions the following:

In connection with the pericyclic reaction of pyridine N-oxides with dipolarophiles, the cycloaddition behavior of some aromatic N-oxides toward electron-deficient allenes was investigated. In the reaction of 2-phenylpyridine N-oxide with di-Me 2,3-pentadienedioate, the 2,3-dihydropyridine type 1:1 cycloadducts I, which resulted from 1,5-sigmatropic rearrangement of the primary cycloadduct, were isolated. The reaction of 3,5-dihalopyridine N-oxides with the allene gave the dehydrohalogenated cycloadducts II (R = Cl, Br). The reaction of 3,5-dimethylpyridine N-oxide with the allene caused deoxygenation to give 3,5-dimethylpyridine, which in turn reacted with two mols. of the allene to give 1:2 cycloadduct (1,4-dipolar cycloaddition product) III. The mol. structure of III was determined by single crystal x-ray anal. The observed reaction behaviors are discussed in terms of frontier MO considerations. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Computed Properties of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Directed Lithiation of 3-[(tert-Butoxycarbonyl)amino]-2-methoxypyridines: Synthetic Route to Nevirapine and Its 4-Substituted Derivatives was written by Kelly, Terence A.;Patel, Usha R.. And the article was included in Journal of Organic Chemistry in 1995.Synthetic Route of C7H10N2O This article mentions the following:

The directed lithiation of 3-[(tert-butoxycarbonyl)amino]-2-methoxypyridines produces a variety of 4-substituted derivatives A general route to 4-substituted dipyridodiazepinones, culminating in the synthesis of the antiviral nevirapine (I) is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Synthetic Route of C7H10N2O).

2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H10N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of G protein-coupled receptor 119 agonist MBX-2982 was written by Ding, Lu;Luo, Tang;Song, Kai-zhen;Gong, Ping;Han, Jing. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2012.Synthetic Route of C11H20N2O2S This article mentions the following:

Type 2 diabetes is emerging as a disease of staggering proportions in twenty-first century. MBX-2982, discovered by Metabolex company, is a potential oral first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119. According to the synthetic methods of MBX-2982 in literature, a new route was developed. The target compound was prepared from 4-cyanopiperidine-1-carboxylic tert-Bu ester via five steps including sulfidation, condensation, etherification, deprotection and substitution. The overall yield was 42.8% (based on 4-cyanopiperidine-1-carboxylic tert-Bu ester), which was 12% higher than that reported in the literature. The synthetic methods of intermediate 2, 6 and MBX-2982 were improved. The final structure and some intermediates were confirmed by ¹H-NMR and MS. Compared with the synthetic process in literature, this route has an economic advantage in view of application to in-depth study. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Synthetic Route of C11H20N2O2S).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H20N2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of EST73502, a Dual 娓?Opioid Receptor Agonist and 锜?sub>1 Receptor Antagonist Clinical Candidate for the Treatment of Pain was written by Garcia, Monica;Virgili, Marina;Alonso, Monica;Alegret, Carles;Farran, Joan;Fernandez, Begona;Bordas, Magda;Pascual, Rosalia;Burgueno, Javier;Vidal-Torres, Alba;Fernandez de Henestrosa, Antonio R.;Ayet, Eva;Merlos, Manuel;Vela, Jose Miguel;Plata-Salaman, Carlos R.;Almansa, Carmen. And the article was included in Journal of Medicinal Chemistry in 2020.Formula: C7H9Br2N This article mentions the following:

The synthesis and pharmacol. activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the 锜?sub>1 receptor (锜?sub>1R) and the 娓?opioid receptor (MOR) are reported. A lead optimization program over the initial 4-aryl analogs provided 4-alkyl derivatives with the desired functionality and good selectivity and ADME profiles. Compound I (EST73502) showed MOR agonism and 锜?sub>1R antagonism and a potent analgesic activity, comparable to the MOR agonist oxycodone in animal models of acute and chronic pain after single and repeated administration. Contrary to oxycodone, I produces analgesic activity with reduced opioid-induced relevant adverse events, like intestinal transit inhibition and naloxone-precipitated behavioral signs of opiate withdrawal. These results provide evidence that dual MOR agonism and 锜?sub>1R antagonism may be a useful strategy for obtaining potent and safer analgesics and were the basis for the selection of I as a clin. candidate for the treatment of pain. In the experiment, the researchers used many compounds, for example, 2-(2-Bromoethyl)pyridine hydrobromide (cas: 72996-65-7Formula: C7H9Br2N).

2-(2-Bromoethyl)pyridine hydrobromide (cas: 72996-65-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361) was written by Smolinski, Michael P.;Bu, Yahao;Clements, James;Gelman, Irwin H.;Hegab, Taher;Cutler, David L.;Fang, Jane W. S.;Fetterly, Gerald;Kwan, Rudolf;Barnett, Allen;Lau, Johnson Y. N.;Hangauer, David G.. And the article was included in Journal of Medicinal Chemistry in 2018.Category: pyridine-derivatives This article mentions the following:

The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clin. candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clin. trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Compound 2 is a phase 1 clin. trial candidate that is likely to provide a first in class treatment of malignant glioblastoma and induces 30% long-term complete tumor remission in animal models. The discovery strategy for these compounds iteratively utilized mol. modeling, along with the synthesis and testing of increasingly elaborated proof of concept compounds, until the final clin. candidates were arrived at. This was followed with mechanism of action (MOA) studies that revealed tubulin polymerization inhibition as the second MOA. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Category: pyridine-derivatives).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 2-chloro-3-amino-4-methylpyridine oxychloride cement was written by Xiao, Qing;Liu, Anchang;Tan, Zhenyou;Liu, Fang. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2008.Synthetic Route of C7H5ClN2 This article mentions the following:

2-Chloro-3-amino-4-methylpyridine was synthesized with 4,4-dimethoxy-2-butanone and malononitrile as raw material by Knoevenagel condensation, cyclization, chlorination, hydrolysis and Hoffman reaction, and the overall yield was 57.3% (mol). The objective compound was characterized by IR and ¹H NMR. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Synthetic Route of C7H5ClN2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H5ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem