Day: February 20, 2023

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy was written by Hazra, Sunit;Hirano, Koji;Miura, Masahiro. And the article was included in Organic Letters in 2021.Reference of 59864-31-2 This article mentions the following:

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones I (R = H, Me, cyclohexyloxy, Ph, piperidin-1-yl, etc.; R¹ = H, Me; R² = Me, Et, n-Bu, Bn) with styrenes R³CH=CH₂ [R³ = (cyclohexyloxy)carbonyl, Ph, 2-methylphenyl, etc.] has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones II are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, multiple substituted 2-pyridone III can be prepared via sequential C-H functionalization reactions. In the experiment, the researchers used many compounds, for example, 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2Reference of 59864-31-2).

1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 59864-31-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of N-heteroarenemethyl esters via C-C bond cleavage of acyl cyanides under transition metal-free conditions was written by Lai, Miao;Su, Fangyao;Hu, Jingyi;Wang, Mengzhuo;Zhao, Mingqin;Zhang, Ganlin. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2021.Synthetic Route of C6H6BrNO This article mentions the following:

A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C-C bond cleavage without using any transition metal is demonstrated here. The use of Na₂CO₃/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Synthetic Route of C6H6BrNO).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 婵?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C6H6BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Intensification of High Boiling Point Organic Solvents on SO₂ Absorption in Deep Eutectic Solvents Formed by Hydroxypyridine and 1-Butyl-3-methylimidazolium Chloride was written by Jiang, Bin;Zhang, Congcong;Tantai, Xiaowei;Yang, Na;Zhang, Luhong;Sun, Yongli;Xiao, Xiaoming. And the article was included in Journal of Chemical & Engineering Data.Related Products of 626-64-2 This article mentions the following:

A series of hydrogen bond donors (HBDs) functionalized deep eutectic solvents (DESs) containing both phys. and chem. action sites were synthesized by hydroxypyridine with different structures and proportions plus 1-butyl-3-methylimidazolium chloride (BmimCl). The effects of temperature, partial pressure, HBDs structure, and water content on SO₂ absorption were investigated, and 4-hydroxypyridine (4-Op)/BmimCl (1:2) exhibited the highest SO₂ absorption capacity. In order to decrease the viscosity of absorbent and increase the applicability of 4-Op/BmimCl (1:2), the SO₂ absorption capacities in four hybrid absorbents based on 4-Op/BmimCl (1:2) and four high b.p. organic solvents [sulfone, DMSO, N-methylpyrrolidone (NMP), and 1-methylimidazole (NMI)] were further studied and compared. 4-Op/BmimCl (1:2)-(NMI) showed the best absorption performance; the addition of NMI significantly decreased the viscosity of the absorbent, and the absorption capacity of absorbent was also improved compared with that of pure 4-Op/BmimCl (1:2) absorbent. The SO₂ absorption capacity of hybrid absorbents (mass fraction of NMI 闂?= 0.3) could reach 1.23 g SO₂/g absorbent at 100 kPa SO₂ and 293.15 K, and the viscosity of the absorbent before absorption was only 12 mPa闁荤姾娅ｅ鈧?at 298.15 K. The gravimetric absorption capacity and desorption performance of hybrid absorbents did not change in the continuous absorption-desorption cycle experiments Furthermore, the results of quantum chem. calculation and spectral anal. showed that there were physicochem. mixing interactions between pure DESs and SO₂. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Related Products of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, synthesis and fungicidal activity of isothiazole-thiazole derivatives was written by Wu, Qi-Fan;Zhao, Bin;Fan, Zhi-Jin;Zhao, Jia-Bao;Guo, Xiao-Feng;Yang, Dong-Yan;Zhang, Nai-Lou;Yu, Bin;Kalinina, Tatiana;Glukhareva, Tatiana. And the article was included in RSC Advances in 2018.Computed Properties of C11H20N2O2S This article mentions the following:

3,4-Dichloroisothiazoles can induce systemic acquired resistance (SAR) to enhance plant resistance against a subsequent pathogen attack, and oxathiapiprolin exhibits excellent anti-fungal activity against oomycetes targeting at the oxysterol-binding protein. To discover novel chems. with systemic acquired resistance and fungicidal activity, 21 novel isothiazole-thiazole derivatives were designed, synthesized and characterized according to the active compound derivatization method. Compound 6u, with EC₅₀ values of 0.046 mg L^-1 and 0.20 mg L^-1 against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo, might act at the same target as oxysterol binding protein (PcORP1) of oxathiapiprolin; this result was validated by cross-resistance and mol. docking studies. The expression of the systemic acquired resistance gene pr1 was significantly up-regulated after treating with compound 6u for 24 h (43-fold) and 48 h (122-fold). These results can help the development of isothiazole-thiazole-based novel fungicides. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Computed Properties of C11H20N2O2S).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C11H20N2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A New Photolabile Protecting Group for Release of Carboxylic Acids by Visible-Light-Induced Direct and Mediated Electron Transfer was written by Borak, J. Brian;Falvey, Daniel E.. And the article was included in Journal of Organic Chemistry in 2009.Formula: C7H6N2 This article mentions the following:

A new aqueous-compatible photoinduced electron transfer based photolabile protecting group, namely, (2-cyano-N-methyl-4-pyridinio)methoxy group, has been developed for the release of carboxylic acids from their esters. The reduction potential of this group is more pos. than previous systems, thereby allowing the use of sensitizers with modest oxidation potentials. Release of several carboxylic acids has been demonstrated using tris(bipyridyl)ruthenium(II) as both a direct sensitizer and a mediator for electron transfer between a good donor and the protecting group. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Formula: C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorocarbon derivatives of nitrogen. Part 11. Synthesis of some 2-(trifluoromethyl)imidazo[1,2-a]pyridines from trifluoroacetonitrile was written by Banks, Ronald Eric;Thomson, Julie. And the article was included in Journal of Fluorine Chemistry in 1984.HPLC of Formula: 17281-59-3 This article mentions the following:

The title compound (I; R = Me₃CO₂C), prepared from CF₃CN and pyridinium t-butoxycarbonylmethylide, reacts smoothly with CF₃CO₂H to give the acid (I; R = HO₂C), which was decarboxylated to I (R = H) on heating. The cyano derivative (I; R = cyano) can be obtained via treatment of CF₃CN with pyridinium cyanomethylide, which is sufficiently reactive to effect nucleophilic displacement of fluorine from pentafluoropyridine under mild conditions to give II. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3HPLC of Formula: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Derivatives of pyridine. VII. Strength of union of quinquevalent arsenic in the pyridine nucleus was written by Binz, A.;Roth, C.;Maier-Bode, H.. And the article was included in Justus Liebigs Annalen der Chemie in 1930.Product Details of 13472-81-6 This article mentions the following:

The following solubilities are reported (g. in 100 cc. H₂O, temperature not given): 2-pyridone-5-arsonic acid (I) 1.5; Na Salt (II), needles, 51; di-Na salt (III), 37.7; 2-hydroxypyridine-5-arsonic acid (IV), 2; Na Salt (V) 20; di-Na salt (VI), 28.60. On heating 1/200 mol. with 20 cc. H₂O in a bomb tube at 170闂? the following % As are split off in 8 hrs.: I 13.6; II 10.5; III 87.6; IV trace; V trace; VI 11; data are also given for 150闂?and for 2 and 4 hrs. heating. I (11 g.) and 16 g. Br in dilute AcOH give 8 g. 3,5-dibromo-2-pyridone, m. 207闂? IV, however, adds Br with difficulty and from 11 g. there was obtained only 1 g. of impure Br derivative Nitration of IV in H₂SO₄ gives 21% of the NO₂ derivative obtained from I in 75% yields. The filtrate contains about the same amount of 3-nitro-2-hydroxypyridine-5-arsonic acid, does not m. 250闂? 5-Iodo-2-pyridone and K₃AsO₃ with CuSO₄ in KOH, heated 20 hrs., give 30% of I. Similarly, 3-bromo-5-iodo-2-pyridone gives 25% of the 3-br derivative of I, also obtained by direct bromination of I. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Product Details of 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ闁荤姾娅ｅΛ纭俵闂? in pyridine vs. 150 kJ闁荤姾娅ｅΛ纭俵闂? in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications was written by Liao, Lieqiang;Jia, Xinjian;Lou, Haoxiang;Zhong, Jinlian;Liu, Huijin;Ding, Shunming;Chen, Chao;Hong, Sanguo;Luo, Xuzhong. And the article was included in RSC Advances in 2021.Product Details of 626-64-2 This article mentions the following:

As one of the most important and fruitful methods, supramol. self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-mol.-weight gelator, N,N’-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramol. gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramol. gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution-gel-crystal transition with the extension of aging time. Further anal. suggested that both the crystal and gel had similar assembled structures. The intermol. hydrogen bonding between amide groups and the 闂?闂?stacking interactions between pyridine groups played key roles in gel formation. Addnl., the release behavior of vitamin B12 (VB₁₂) from PDA-N4 gel (H₂O/DMSO, volume/volume = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biol. application in tissue engineering and controlled drug release. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Investigation of DNA/BSA binding and cytotoxic properties of new Co(II), Ni(II) and Cu(II) hydrazone complexes was written by Kanchanadevi, Sivaswamy;Fronczek, Frank R.;Immanuel David, Charles;Nandhakumar, Raju;Mahalingam, Viswanathan. And the article was included in Inorganica Chimica Acta in 2021.SDS of cas: 91-02-1 This article mentions the following:

Two mononuclear complexes of Co(II) (1) and Ni(II) (2) and a chloro bridged binuclear copper(II) complex (3) of 2-benzoylpyridine-4-methoxybenzoylhydrazone have been synthesized in order to explore their biol. activities, such as DNA binding, protein-binding, antioxidant activity and anticancer activity. Anal. and spectroscopic techniques have been used to characterize the complexes. The mol. structures of 2 and 3 have been obtained by single crystal XRD. Interaction of the ligand and the complexes with calf thymus DNA (CT-DNA) has been explored by absorption and emission titrations, which revealed that the compounds interacted with CT-DNA through intercalation. Absorption titration and biol. studies revealed that the complexes interact with BSA through different binding modes to different extents. The radical scavenging ability of the ligand and the complexes was studied against DPPH radicals. The ligand and its metal complexes were tested for potential cytotoxicity towards human breast cancer (MCF-7) and lung cancer (A-549) cell lines. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem