Month: August 2023

Ruthenium-Catalyzed Meta-Selective C-H Difluoromethylation of Phenol Derivatives was written by Xu, Xu;Tao, Na;Fan, Wei-Tai;Tu, Guangliang;Geng, Jingyao;Zhang, Jingyu;Zhao, Yingsheng. And the article was included in Journal of Organic Chemistry in 2020.Synthetic Route of C11H9NO This article mentions the following:

With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladacycles of sulfated and selenated Schiff bases of ferrocene-carboxaldehyde as catalysts for O-arylation and Suzuki-Miyaura coupling was written by Sharma, Alpesh K.;Joshi, Hemant;Bhaskar, Renu;Kumar, Satyendra;Singh, Ajai K.. And the article was included in Dalton Transactions in 2017.COA of Formula: C11H9NO This article mentions the following:

Schiff base ligands (L1: sulfated and L2: selenated) having a ferrocene core synthesized by reacting ferrocene-carboxaldehyde with 2-(phenylthio/seleno)ethylamine on treatment with Na₂PdCl₄ in the presence of NaOAc give cyclopalladated complexes [Pd(L1/L2-H)Cl] (1/2). Complex 1 of a sulfated Schiff base L1, on reacting with one equivalent of triphenylphosphine gives complex [Pd(L1-H)PPh₃Cl] (3), formed due to cleavage of a Pd-S bond. With 2 such a reaction does not occur, as a Pd-Se bond being stronger than that of its sulfur analog does not get cleaved. L1, L2 and their complexes 1–3 were authenticated with HR-MS, ¹H, ¹³C{¹H} and ⁷⁷Se{¹H} NMR spectroscopy. The single crystal structures of 1–3 were determined with x-ray diffraction. Palladium in all three complexes has nearly a square planar geometry. The Pd-S, Pd-Se and Pd-P bond distances are 2.4249(12), 2.5058(14) and 2.2445(17) 闂?resp. The catalytic activity of complexes 1–3 was explored for O-arylation of phenol and Suzuki-Miyaura coupling (SMC) of phenylboronic acid with aryl bromides and chlorides. The optimum reaction time for SMC of ArBr is 3 h whereas for ArCl it is 6 h. The TON values of O-arylation catalyzed with complexes 1–3 are up to 闂?70 (TOF, 28 h^-1) and SMC 闂?300 (TOF, 3100 h^-1) for the reaction time of the order of 3 and 6 h resp. The catalytic process is somewhat more efficient with 2 (Pd bonded with a selenoether group), than 3, followed by 1. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0COA of Formula: C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem