闁?Silicon-effect-promoted intermolecular site-selective C(sp3)-H amination with dirhodium nitrenes was written by Ninomiya, Ryo;Arai, Kenta;Chen, Gong;Morisaki, Kazuhiro;Kawabata, Takeo;Ueda, Yoshihiro. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Application In Synthesis of Pyridinehydrochloride This article mentions the following:
A dirhodium-catalyzed, 闁?selective C-H amination of organosilicon compounds was developed. Primary C(sp3)-H bonds of silylethyl groups and secondary C(sp3)-H bonds of silacycloalkanes can be selectively converted to C-N bonds at the 闁?position of the Si atoms. The exptl. data and theor. calculations indicate that the strong 闂?donor ability of the C-Si bonds is responsible for the 闁?selectivity. Kinetic isotope effects clearly demonstrate that the C-H bond cleavage step is not turnover-limiting, but selectivity-determining In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Pyridinehydrochloride