Rare-earth catalyzed C-H bond activation and alkylation of pyridines was written by Guan, Bingtao;Hou, Zhaomin. And the article was included in Kidorui in 2012.Quality Control of 2-Isopropylpyridine This article mentions the following:
An efficient and general protocol for the alkylation of various pyridine derivatives via C-H addition to olefins has been developed by the use of cationic half-sandwich rare-earth catalysts, which provides an atom-economical method for the synthesis of alkylated pyridine derivatives A wide range of olefin substrates including ethylene, 婵?olefins, styrenes and conjugated dienes are compatible with the catalysts. The authors have demonstrated that half-sandwich rare-earth dialkyl complexes such as (C5Me5)Ln(CH2C6H4NMe2-o)2 (Ln = Sc, Y) in combination with an activator such as B(C6F5)3 can serve as an excellent catalyst for the ortho-selective C-H addition of pyridines to a variety of olefins such as 1-alkenes, styrenes and 1,3-conjugated dienes to afford straightforwardly a series of alkylated pyridine derivatives in an atom-economical way. The present rare-earth catalysts are complementary to late transition metal catalysts in terms of selectivity, functional group tolerance and substrate scope. Further studies on rare-earth catalyzed C-H functionalizations with other substrates are in progress. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Quality Control of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 婵?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 2-Isopropylpyridine