Syntheses of [11C]2- and [11C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases was written by Ramos-Torres, Karla M.;Zhou, Yu-Peng;Yang, Bo Yeun;Guehl, Nicolas J.;Sung-Hyun, Moon;Telu, Sanjay;Normandin, Marc D.;Pike, Victor W.;Brugarolas, Pedro. And the article was included in RSC Medicinal Chemistry in 2020.Recommanded Product: 257937-08-9 This article mentions the following:
Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabeled 4-aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases. Here, we describe methods for producing 11C-trifluoromethylated derivatives of 4AP and present early imaging results with [11C]3-trifluoromethyl-4AP in a rhesus macaque. This study shows the utility of [11C]CuCF3 for labeling pyridines and provides initial evidence for the potential use of [11C]3-trifluoromethyl-4AP as a PET radioligand. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Recommanded Product: 257937-08-9).
tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 257937-08-9