Synthetic Route of 53937-02-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone. A new synthetic method of this compound is introduced below.
c) 4-(Benzyloxy)- 1 -( 1 -(2-(pyrrolidin- 1 -yl)ethyl)- lNo.-indazol-5-yl)pyridin-2( lNo.)-one; Chemical Formula C25H26N4O2Exact Mass 414 21 Molecular Weight 414 5 [0081] A suspension of 5-bromo-l-(2-(pyrrolidin-l-yl)ethyl)-lH-indazole (0 21 g, 0.70 mmol) in 1,4-dioxane (10 mL) stirred under nitrogen was treated sequentially with 4- (benzyloxy)pyridin-2(li/)-one (0.14 g, 0.70 mmol), trans- 1,2-diaminocyclohexane (0.03 mL, 0.2 mmol), CuI (28 mg, 0.15 mmol) and K2CO3 (0.19 g, 1 4 mmol). After stirring overnight at 1100C, the mixture was allowed to cool to room temperature, diluted with CH2Cl2, washed with brine, dried over Na2SO4, filtered and concentrated to dryness. Purification by flash column chromatography (silica gel, CH2Cl2/Me0H, 95:5 to 90: 10) gave the title compound (21 mg, 7%) as an off-white powder 1H NMR (500 MHz, DMSO-J6) delta 8.03 (s, IH), 7.66 (d, J = 1.4 Hz, IH), 7.53 (d, J = 8.8 Hz, IH), 7.43-7.36 (m, 6H), 7.28 (d, J = 7.5 Hz, 1 H), 6.09-6.06 (m, 2H), 5.06 (s, 2H), 4.58-4.55 (m, 2H), 3.03 (br m, 2H), 2 61 (br m, 4H), 1.81 (br m, 4H); ESI MS m/z 415 [M + H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,53937-02-3, 4-Benzyloxy-2-(1H)-pyridone, and friends who are interested can also refer to it.
Reference:
Patent; AMR TECHNOLOGY, INC.; WO2008/86404; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem