Synthetic Route of 82671-06-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 82671-06-5 as follows.
In a round-necked flask 2,6-dichloro-5-fluoro-nicotinic acid (20.0g, 95.2mmol), sodium methoxide (11.3g, 210mmol) and anhydrous methanol (with 260 mL of), the reaction was refluxed for 4 hours, cooled to at room temperature, was added 200mL of water, acidified with concentrated hydrochloric pH = 1, then extracted with ethyl acetate, dried over anhydrous Na2SO4Dried, the solvent was spin-product 19.0g, a yield of 97.4%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,82671-06-5, its application will become more common.
Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology co., LTD; WU, YONG QIAN; WANG, AI CHEN; (35 pag.)CN102887895; (2016); B;,
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