Adding a certain compound to certain chemical reactions, such as: 1008-91-9, 1-(Pyridin-4-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H13N3, blongs to pyridine-derivatives compound. Computed Properties of C9H13N3
The crude material (1.15 g, 7.06 mmol) from Step B was dissolved in dichloromethane (50 mL). After addition of diisopropylethylamine (4.7 mL, 42.4 mmol), 3-nitrosali-cylic acid (1.94 g, 10.6 mmol), and PyBrOP (5.78 g, 12.3 mmol), the resulting mixture was stirred over night at room temperature before being put into IN sodium hydroxide (300 mL). Extraction with dichloromethane (2×100 mL) removed all PyBrOP products. The aqueous phase was carefully acidified to pH~5-6 with 3N HC1 and extracted with dichloromethane (3×100 mL). The combined organic layers of the neutral extraction were dried over sodium sulfate, concentrated, and finally purified by column chromatography (dichloromethane/methanol/NH4OH=10/l/0.1) to yield the desired product (850 mg, 37% for 2 steps).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1008-91-9, 1-(Pyridin-4-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Patent; Schering Corporation and Pharmacopeia, Inc.; US2004/147559; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem