Synthetic Route of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A) Synthesis of 2,6-bis-(chloromethyl)pyridine To thionyl chloride (11.6 ml, 158 mmoles), cooled at 0 C., 2,6-bis-(hydroxymethyl)pyridine (4 g, 28 mmoles) is added very slowly. The obtained solution is left under stirring for 2 hours at room temperature, then the thionyl chloride in excess is evaporated at a reduced pressure. The obtained residue is treated with chloroform and it is evaporated again at a reduced pressure to remove the thionyl chloride residues. The raw product is treated with chloroform and washed with water. The organic phase is anhydrified with sodium sulphate and dried obtaining 4.81 g of the product as white solid having melting point=76-78 C.
The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Del Soldato, Piero; Benedini, Francesca; Antognazza, Patrizia; US2004/23933; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem