In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1180132-17-5, name is 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 1180132-17-5
Compound 8a (216 mg, 0.7 mmol), compound 12 (154 mg, 0.7 mmol), sodium carbonate (74 mg, 0.7 mmol), 4 5-bisdiphenylphosphino-9 9-dimethyloxanthene (Xantphos) , 121 mg, 0.21 mmol) dissolved in 1,4-dioxane (20 mL), added with palladium acetate (16 mg, 0.07 mmol) under nitrogen atmosphere, reacted at 90 C for 10 hours, and the reaction solution was cooled to room temperature. into 50 mL of water, extracted three times with dichloromethane (30mL x3), the organic phases were combined, dried over anhydrous sodium sulfate filtered, and spin dry solid was recrystallized from ethyl acetate to give a yellow solid T-1 (150 mg, 44%) .
The synthetic route of 1180132-17-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hangzhou Bai Cheng Pharmaceutical Technology Co., Ltd.; Sheng Rong; Lou Jinfang; Zhang Fengmin; Luo Jin; Wu Lijun; Yang Huan; Jin Zewu; Xiong Xiaohong; Qian Yang; (32 pag.)CN110156754; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem