Application of 52605-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52605-98-8, name is 5-Bromo-2,3-dimethoxypyridine, molecular formula is C7H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
As shown in step 2-v of Scheme 2, compound 1005 was suspended in 200 mL of dry THF along with PdCl2(Ph3P)2 (1.56 g, 2.23 mmol) and Ph3P (300 mg, 1.114 mmol). The mixture was flushed with N2 for 10 minutes. Triethylamine (14.0 mL, 10.14 g, 0.1 mol) and trimethylsilylacetylene (11.3 mL, 7.84 g, 0.080 mmol) were added under a nitrogen atmosphere and stirring continued for 15 minutes more before the addition of Cu(I) iodide (500 mg; 2.65 mmol). The reaction mixture was stirred at ambient temperature for 4 hours, and then heated for 5 hours at 40 C. under N2. The mixture was suction filtered through a pad of diatomaceous earth, which was washed with additional THF. The volatiles were removed under reduced pressure. The residue was dissolved in DCM, washed with water (2*), brine, and dried over Na2SO4. After filtration, the volatiles were removed under reduced pressure and the residue purified by silica gel chromatography (DCM) to provide 2,3-dimethoxy-5-((trimethylsilyl)ethynyl)pyridine (5.7 g) as a beige solid: ESMS (M+1)=236; 1H NMR (CDCl3) delta 7.89 (d, J=1.88 Hz, 1H), 7.1 (d, J=1.88 Hz, 1H), 4.02 (s, 3H), 3.89 (s, 3H), 0.12 (s, 9H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52605-98-8, 5-Bromo-2,3-dimethoxypyridine.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2011/81316; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem