Related Products of 142404-69-1, Adding some certain compound to certain chemical reactions, such as: 142404-69-1, name is 2-(Chloro(4-chlorophenyl)methyl)pyridine,molecular formula is C12H9Cl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 142404-69-1.
General procedure: To a stirred solution of (1-(2-phenoxyethyl)piperidin-4-yl)methanol (0.3 g, 1.27 mmol) in THF (5 mL) was added sodium hydride (0.046 g, 1.9 mmol, 1.5 equiv) and 10 minutes later, 2-(chloro(4-chlorophenyl)methyl)pyridine (0.304 g, 1.27 mmol, 1.0 equiv) at room temperature. The reaction mixture was heated at 80 C and stirred for 16 h. After completion,water was added to the reaction mixture and extracted with EtOAc. The combined organic extract was washed with brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification using prep HPLC purification to furnish 0.0 12 g of 2-((4- chlorophenyl)(( 1 -(2-phenoxyethyl)piperidin-4-yl)methoxy)methyl)pyridine (Yield = 2%). 1H NMR (400 MHz, CD3OD-d4): 8.45-8.43 (m, 1H), 7.86-7.82 (m, 1H), 7.62-7.60 (m, 1H),7.39-7.36 (m, 2H), 7.32-7.23 (m, 5H), 6.93-6.89 (m, 3H), 5.42 (s, 1H), 4.12 (t, 2H, J =5.6Hz), 3.36 (d, 2H, J = 6.0Hz), 3.07 (d, 2H, J = 11.6Hz), 2.82 (t, 2H, J = 5.6Hz), 2.22-2.16 (m, 2H), 1.89-1.69 (m, 3H), 1.46-1.36 (m, 2H); ESI+ MS: m/z: 437 ([M + Hj).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 142404-69-1, 2-(Chloro(4-chlorophenyl)methyl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
Pyridine – Wikipedia,
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