Electric Literature of 18368-64-4 ,Some common heterocyclic compound, 18368-64-4, molecular formula is C6H6ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Chloro-5-methylpyridine (10.03 g, 79 mmol), (3-chloro-4-methylphenyl)boronic acid (13.4 g, 79 mmol), and potassium carbonate (21.74 g, 157 mmol) were dissolved in the mixture of DME (150 ml) and water (20 ml) under nitrogen to give a colorless suspension. Pd(PPh3)4(0.909 g, 0.786 mmol) was added to the reaction mixture, then the reaction mixture was degassed and heated to 95° C. for 12 hrs. It was then cooled down to room temperature, separated organic phase and evaporated. The residue was subjected to column chromatography on silica gel column, eluted with heptanes/THF 9/1 (v/v), providing after crystallization from heptanes 10 g of 2-(3-chloro-4-methylphenyl)-5-methylpyridine (58percent yield) of white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18368-64-4, 2-Chloro-5-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Worldwide Show Corporation; Cai Ruiyi; Ji Zhiqiang; Ya Likexi·baolisuoweiqi·diyatejin; Xia Chuanjun; Lin Chun; Zeng Lichang; Wo Erte·yegeer; (191 pag.)CN107522748; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem