Reference of 1034667-22-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1034667-22-5 as follows.
Formation of 3-bromo-5-fluoro-lH-pyrazolo[3,4-Z>] pyridine (4)To a mixture of 5-fluoro-lH-pyrazolo[3,4-0]pyridin-3-arnine, 3, (0.88 g, 5.79 mmol) in bromoform (8.8 mL) was added /eri-butyl nitrite (1.38 mL, 1 1.57 mmol). This mixture was heated to 61 C for 1 h and then heated to 90 C for an additional hour. The mixture was cooled to room temperature and bromoform was removed under reduced pressure. The resulting crude – residue was purified by silica gel chromatography (5-50% ethyl acetate/hexanes) to afford 970 mg of the desired product as a white solid: NMR (300 MHz, DMSO-i/6) delta 14.22 (s, 1 H), 8.67 (dd, J = 2.7, 1.9 Hz, 1 H), 8.07 (dd, J = 8.2, 2.7 Hz, 1 H); LCMS Gradient 10-90%, 0.1% formic acid, 5min, C18/ACN, Retention Time = 2.42 min (M+H) 216.1 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1034667-22-5, its application will become more common.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, Paul, S.; CLARK, Michael, P.; DAVIES, Ioana; GAO, Huai; KENNEDY, Joseph, M.; LEDEBOER, Mark, W.; MALTAIS, Francois; PEROLA, Emanuele; WO2012/83121; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem