The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 945717-09-9, name is 2-Chloro-4-ethynylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-4-ethynylpyridine
To a solution of the compound i18 (1g, 1.95mmol) in DMF (10mL) was added Et3 N (0.812mL, 5.86mmol), 2-chloro-4-ethynylpyridine (806mg, 5.86mmol), copper iodide (37.2mg, 0.195mmol), and PdCl2 (PPh3)2(137mg,0.195mmol), the mixture was stirred under nitrogen atomosphere at 100 C for 1 hour. Water was added to the reactionsolution, extracted with ethyl acetate, and the organic layer was washed water, dried over anhydrous sodium sulfate,concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane – ethylacetate) to yield the compound 23 (574mg, yield 56%). LC/MS (ESI):m/z = 522.20 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 945717-09-9.
Reference:
Patent; Shionogi & Co., Ltd.; KAWASUJI, Takashi; TANIYAMA, Daisuke; SUGIYAMA, Shuichi; TAMURA, Yoshinori; (153 pag.)EP3144311; (2017); A1;,
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