Synthetic Route of 6188-23-4 , The common heterocyclic compound, 6188-23-4, name is 6-Bromoimidazo[1,2-a]pyridine, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of 38A (1.0 g, 5.08 mmol) in THF (60 mL) under argoncondition was added NaH (0.122 g, 5.08 mmol, 60 % in mineral oil). The reactionmixture was stirred at RT for 30 mm. and to it was added Selectfluor (3.87 g, 10.92 mmol) in acetonitrile (10 mL). The reaction mixture was heated at 70 C for another 20 h. The reaction mixture was quenched with saturated aq. NH4C1 solution (100 mL) and was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were dried overanhydrous sodium sulfate, filtered and the filtrate evaporated under reduced pressure to get a brown gum. The crude product was purified by silica gel chromatography (24 g RediSep column, eluting with a gradient of 17-19 % EtOAc in petroleum ether). Fractions containing the desired product were combined and evaporated under reduced pressure to afford intermediate 38B (0.1 g, 9.16 % yield). LCMS: m/z = 215.3 [M+HjHPLC Ret. Time 0.37 mm. (HPLC Method D).
The synthetic route of 6188-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; LIU, Peiying; TEBBEN, Andrew J.; VELAPARTHI, Upender; RAHAMAN, Hasibur; TONUKUNURU, Gopikishan; WARRIER, Jayakumar Sankara; (264 pag.)WO2018/17633; (2018); A1;,
Pyridine – Wikipedia,
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