Related Products of 1072-97-5 , The common heterocyclic compound, 1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-Bromo-2-aminopyridine (5.19 g, 30 mmol) was dissolved in 100 mL of anhydrous dichloromethane.20 ml of triethylamine was added. In ice bath conditions,Slowly add acetyl chloride (2.54 ml) to the above solution, after the addition is completed,The ice bath was removed and allowed to warm to room temperature overnight. After the reaction,Dilute with dichloromethane,Washed (30ml × 3), washed with saturated NaHCO3 solution (30ml × 3),The mixture was washed with saturated NaCl (30 mL) and dried over anhydrous Na2SO.Column chromatography to obtain a white solid5.65 g, yield 88%.
The synthetic route of 1072-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (15 pag.)CN109796439; (2019); A;,
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