As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 128071-98-7, name is 4-Bromo-2-fluoropyridine, molecular formula is C5H3BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-Bromo-2-fluoropyridine
To a solution of 4-[[4-nitro-3-(trifluoromethyl)phenyl]amino]cyclohexan-l-ol (15 g, 49 mmol) in N-dimethylformamide (50 mL) was added sodium hydride (5.9 g, 246 mmol) The mixture was stirred for 30 minutes at 0 C. To this was added 4-bromo-2-fluoropyridine (8.7 g, 49 mmol). The resulting solution was stirred for 2 hours at 65 C. The reaction was then quenched by the addition of water. The resulting solution was extracted with ethyl acetate and the organic layers were combined and dried over anhydrous sodium sulfate before concentration under vacuum. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1 :20?1 :5). Concentration of the product containing fractions provided 15.3 g (67%) of 4-nitro- V-[4-[(4-bromopyridin-2- yl)oxy]cyclohexyl]-3-(trifluoromethyl)aniline as a yellow solid; NMR (300 MHz, DMSO): delta 8.08 – 8.05 (m, 2H), 7.52 – 7.49 (m, 1H), 7.21 – 7.09 (m, 3H), 6.90 – 6.86 (m, 1H), 5.05 – 4.91 (m, 1H), 3.61 – 3.51 (m, 1H), 2.10 – 2.08 (m, 4H), 1.66 – 1.54 (m, 2H), 1.45 – 1.33 (m, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 128071-98-7.
Reference:
Patent; MERIAL INC.; LONG, Alan; WILKINSON, Douglas, Edward; (224 pag.)WO2016/118638; (2016); A1;,
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