In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 70201-42-2, name is 3,5-Dibromoisonicotinaldehyde, the common compound, a new synthetic route is introduced below. Quality Control of 3,5-Dibromoisonicotinaldehyde
To a solution of N-benzyloxycarbonyl-a-phosphono-glycine trimethyl ester (29.7 g, 89.7 mmol) in anhydrous DCM (500 mL) was added diazabicycloundec-7-ene (0.1 M solution in DCM, 14.6 mL, 97.9 mmol) dropwise. The reaction mixture was stirred for about 20 minutes at room temperature then a solution of 3,5-dibromo-pyridine-4-carbaldehyde (21.5 g, 81.6 mmol) in DCM (300 mL) was added dropwise and the resulting reaction mixture was stirred at room temperature for about 2 hours. The solvent was removed in vacuo and the resulting semi-solid taken up in EtOAc (500 mL) and washed with IN aqueous HCl (3 x 150 mL). The organic phase was separated, dried over sodium sulfate, and the solvent removed in vacuo. The resulting semi-solid was triturated using a 2:1 mixture of heptane-ethyl ether to provide 2-benzyloxycarbonyla»zirzo-3-(3,5-dibromo-pyridirz-4-yl)-acrylic acid methyl ester as an off-white powder (32.4 g, 69.1 mmol) ; ¹H NMR (d6-DMSO, 400 MHz): 8 9.44 (1H, bs), 8.72 (2H, s), 7.30-7.41 (5H, m), 6.59 (lH, s), 5.05 (2H, s), and 3.74 (3H, s) ; RP-HPLC (Table 1, Method n) Rt 4.18 min (major isomer); 111/Z: (M + H)(at) 471.
The synthetic route of 70201-42-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem