Synthetic Route of 58539-77-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58539-77-8, name is 3-(Chloromethyl)-2-methylpyridine hydrochloride. A new synthetic method of this compound is introduced below.
A mixture of the compound of Example 42 (0.20 g, 0.57 [MMOL),] cesium carbonate (2.0 g, 5.7 [MMOL)] and 3-chloromethyl-2-methyl-pyridine hydrochloride (0.16 g, 0.91 [MMOL)] in a 2: 1 THF/DMF mixture was heated at [80C] for 15 hours. The cooled mixture was filtered and concentrated, and then water (30 mL) was added and the mixture extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with brine, dried [(MGS04),] filtered and concentrated to a foam (0.31 [G).] The residue was purified by flash chromatography using a 30% to 70% ethyl acetate/hexanes eluant to afford 122 mg (47%) of the title compound as an oil. Mass spectrum: (m/e) 458 (M++1, +ion).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58539-77-8, its application will become more common.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/5229; (2004); A1;,
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