With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, molecular weight is 163.22, as common compound, the synthetic route is as follows.Recommanded Product: 1008-91-9
General procedure: To the stirred solution of 6 (0.29 g, 0.001 mol) in dry THF, HOBt (0.16 g, 0.012 mol) and EDCI*HCl (0.23 g, 0.012 mol) were added and continued stirring for 30 min. To the reaction mixture, substituted phenylpiperazine (0.001 mol) was added under ice cold temperature and the reaction mixture was further stirred at room temperature for 6 h. After completion of reaction as monitored byTLC, solvent was evaporated under vacuum. Reaction mixture was extracted with ethyl acetate (2 x 20 mL), collected organic layer was dried over anhydrous Na2SO4, concentrated under vacuum and passed through small bed of silica gel (60e120) using mobile phase (ethyl acetate:hexane; 3:7) to obtain analytically pure final product 7.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1008-91-9, 1-(Pyridin-4-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Article; Penta, Ashok; Franzblau, Scott; Wan, Baojie; Murugesan, Sankaranarayanan; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 238 – 244;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem