The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1335210-23-5, name is 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
100 g of compound (2) was charged along with acetonitrile 800 ml followed by acetic acid 100 ml and methane sulphonic acid 5 ml. The contents were heated at 70-80C and maintained for 6-8 hours. The reaction mass was cooled to room temperature and 52 g of compound (4) was added to it followed by addition of potassium carbonate 52.5 g. The reaction mass was stirred for 16-18 hours and 1000 ml of water was added to the reaction mass and then extracted with dichloromethane 1000 ml. The reaction mass was re-extracted two more times with dichloromethane. The combined organic layer was washed with water 500 ml and concentrated to get residue. 300 ml of methanol was charged to the residue and stirred for 30 minutes and then filtered. The residue was washed with methanol 50 ml and then dried and then recrystallized from dichloromethane / methyl tert-butyl ether to get pure compound (5).Yield-70gHPLC Purity: > 99.5 %
With the rapid development of chemical substances, we look forward to future research findings about 1335210-23-5.
Reference:
Patent; CIPLA LIMITED; PHULL, Manjinder Singh; RAO, Dharmaraj Ramachandra; BIRARI, Dilip Ramdas; (28 pag.)WO2018/229798; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem