Reference of 10366-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10366-35-5, name is 2-Chloronicotinamide, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A microwave reaction tube was charged with an amide (1 equiv.), PdCl2(MeCN)2 (5 mol%) and BINAP (5 mol%), The tube was evacuated and backfilled with argon (3 times), and then dry DMF (4 mL/1 mmol of starting material), phenylacetylene (1.5 equiv.), and DBU (2 equiv.) were added. The mixture was sparged with argon for 5 min and then irradiated under microwaves at 120 C for 30 minutes. After cooling to room temperature, the solvent was partially removed in vacuo, then the mixture was diluted in EtOAc (10 mL), washed with water (5 mL) and brine (5 mL). The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated. The crude product was purified by chromatography on silica gel to give the desired product.
According to the analysis of related databases, 10366-35-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Hellal, Malik; Cuny, Gregory D.; Tetrahedron Letters; vol. 52; 42; (2011); p. 5508 – 5511;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem