Synthetic Route of 52605-98-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-98-8, name is 5-Bromo-2,3-dimethoxypyridine, molecular formula is C7H8BrNO2, molecular weight is 218.05, as common compound, the synthetic route is as follows.
5,6-Dimethoxynicotinaldehyde (42) To a solution of 5-bromo-2,3-dimethoxypyridine (41, 21.7 g, 99.5 mmol) in anhydrous tetrahydrofuran (200 mL) was dropwise added n-butyl lithium (48.0 mL, 2.5 mol/L in hexane) at -78 C. under N2. The mixture was stirred for at -78 C. for 1 h. Then N, N-dimethylformamide (16.2 mL) was added to the mixture at -78 C. The reaction mixture was stirred for another 30 min at -78 C. After the reaction was completed, the mixture was quenched by saturated NH4Cl(sat.), extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated in vacuo. The residue was purified by flash chromatogram with ethyl acetate/petroleum ether (1:3) to afford 5,6-dimethoxynicotinaldehyde (42) as a yellow solid (13.5 g, 81%). ESI-MS, m/z=168 [M+H]+.
Statistics shows that 52605-98-8 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2,3-dimethoxypyridine.
Reference:
Patent; Tsai, Guochuan Emil; Wang, Ching-Cheng; Hsieh, Yuan-Ting; (53 pag.)US2019/112289; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem