As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
A mixture of 3-chloro-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-l-yl)piperidin-l- yl]pyrazine-2-carbonitrile (322 mg, 1.00 mmol), tert- butyl 4-(5-aminopyridin-2- yl)piperazine-l -carboxylate (293 mg, 1.05 mmol), (acetyloxy)palladio acetate (74 mg, 0.33 mmol), [2′-(diphenylphosphanyl)-[l, T-binaphthalen]-2-yl]diphenylphosphane (206.27 mg, 0.33 mmol) and CS2CO3 (981 mg, 3.01 mmol) was degassed and backfilled with N2 5 times. The mixture was allowed to stir at 100 C for 90 min. The mixture was filtered through Celite washing with MeOH/EtOAc, concentrated and purified by MPLC (0-100% EtOAc in CH2CI2) to afford /er/-butyl 4-[5-({3-cyano-6-[(3R)-3-(3-methyl-2-oxoimidazolidin-l- yl)piperidin- 1 -yl]pyrazin-2-yl } amino)pyridin-2-yl]piperazine- 1 -carboxylate (0.2920 g, 51.7%).
With the rapid development of chemical substances, we look forward to future research findings about 119285-07-3.
Reference:
Patent; NURIX THERAPEUTICS, INC.; ROBBINS, Daniel, W.; SANDS, Arthur, T.; MCINTOSH, Joel; MIHALIC, Jeffrey; WU, Jeffrey; KATO, Daisuke; WEISS, Dahlia; PENG, Ge; (415 pag.)WO2020/81450; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem