Application of 77992-44-0, Adding some certain compound to certain chemical reactions, such as: 77992-44-0, name is (5-Bromopyridin-2-yl)hydrazine,molecular formula is C5H6BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 77992-44-0.
5-(methoxycarbonyl)-2-methylbenzoic acid (1.03 g, 5.32 mmol) was dissolved in 20 ml of 1 ,4-dioxane, followed by the dropwise addition of oxalyl chloride (0.464 ml, 5.32 mmol). The mixture was stirred at room temperature for 2 hours. The solution was then added dropwise to a suspension of 5-bromo-2-hydrazinopyridine (1.0 g, 5.3 mmol) in diisopropylethylamine (1.85 ml, 10.6 mmol) and 5 ml of dioxane at 0 0C. After 15 minutes, phosphorus oxychloride (0.974 ml, 10.6 mmol) was added and the reaction stirred at 100 0C overnight. The reaction was cooled, evaporated to about half the solvent volume and quenched with 100 ml of a NaHCO3 solution. The reaction mixture was extracted 2 times with 100 ml of ethyl acetate and the combined organic layers were washed with 100 ml of a NH4CI solution and 100 ml of brine, dried over MgSO4 and evaporated. The resulting residue was purified using silica gel chromatography to obtain a dark oil. The oil was triturated with 20 ml of ether and the resulting solid was dried in vacuo to give a tan solid (450 mg, 24% yield). 1H NMR (400 MHz, DMF-d?) delta 8.59 (s, 1 H), 8.19 (d, J= 1.5 Hz1 1H), 8.11 (dd, J= 8.1 , 1.7 Hz, 1 H), 7.89 (d, J= 9.4 Hz 1 H), 7.66 (d, J= 8.1 Hz, 1 H), 7.59 (dd, J= 9.7, 1.6 Hz, 1H), 3.90 (s, 3H), 2.32 (s, 3H); LC/MS, tr = 2.07 minutes (5 to 95% acetonitrile/water over 5 minutes at 1 ml/min, at 254 nm, at 50 0C), ES-MS m/z 346 (M+H). ES- HRMS m/z 346.0212 (M+H calcd for C15H13BrN3O2 requires 346.0186).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 77992-44-0, (5-Bromopyridin-2-yl)hydrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY LLC; WO2006/18735; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem