Synthetic Route of 137628-17-2 , The common heterocyclic compound, 137628-17-2, name is 2,3-Dibromo-5-chloropyridine, molecular formula is C5H2Br2ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 16i 3-Bromo-5-chloropicolinonitrile 2,3-Dibromo-5-chloropyridine (14 g, 51.6 mmol), copper(I) cyanide (5.09 g, 56.79 mmol) and propionitrile (58 mL) were divided into four vials and each vial was heated in a microwave reactor at 150 C. for 2.5 h. The mixtures were pooled, filtered and concentrated. The resulting residue was taken up in DCM (100 mL), a solid was filtered off and the filtrate was concentrated to afford 11.3 g (quantitative yield) of the title compound: MS (CI) m/z 217, 219 [M+H]+.
The synthetic route of 137628-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; US2010/125081; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem