Related Products of 499-51-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 499-51-4 as follows.
Dimethyl-4-bromo-2,6-pyridinedicarboxylate (Compound 2) A mixture of chelidamic acid monohydrate (8.42 g, 41.87 mmol) and PBr5 (93 g) in a dry Shlenk tube equipped with a reflux condenser was heated under a nitrogen atmosphere to 120 C. A melt formed which was stirred under a nitrogen atmosphere for 3 hours at 100 C. The resultant purple melt was cooled to room temperature and transferred to a round bottom flask equipped with a drying tube by washing with CHCl3 (3×50 mL). The solution was cooled to 0 C. and dry MeOH (150 mL) was slowly added. The resultant brown solution was stirred overnight and then concentrated in vacuo to a slurry. Solid was recrystallised from MeOH (175 mL), filtered, washed with ice cold MeOH (3×50 mL) and sucked dry, giving 2 as white needles (8.29 g, 72%) 1H NMR (299.9 MHz, CDCl3) delta 8.46 (s, 2H, Ar-H), 4.04 (s, 6H, -OCH3) ppm; 13C NMR (125.7 MHz, CDCl3) delta 164.36 (carbonyl), 149.42 (aromatic), 135.37 (aromatic), 131.66 (protonated aromatic), 53.83 (methyl) ppm; Anal. Calcd. for C9H8NO4Br: C: 39.43, H: 2.94, N: 5.11, Found: C: 39.68, H: 2.92, N: 5.09; m.p. 166-167 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,499-51-4, its application will become more common.
Reference:
Patent; Medical Research Council; University of Otago; US2004/29851; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem