Related Products of 137628-17-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137628-17-2, name is 2,3-Dibromo-5-chloropyridine, molecular formula is C5H2Br2ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of compound 47.1 (10.0 g, 37.19 mmol) in THF (100 ml) was added slowly asolution of isopropylmagnesium chloride/lithium chloride (1.3 M in THF, 31 ml, 40.3 mmol)at -40 C. The solution was stirred for 30 mm at -40 C and DMF (8.5 ml, ill mmol) wasadded. The resulting solution was warmed to room temperature and stirred for 30 mm. Thereaction was quenched with 1M HCI (70 ml) and diethyl ether (60 ml) was added. The organic layer was separated and washed with 5% aqueous NaHCO3. The solvent was removed under vacuum. The resulting solids were dissolved in methanol (90 ml). Thesolution was cooled to 0 C NaBH4 (3.60 g, 95.2 mmol) was slowly added. The reaction mixture was stirred for 30 mm, then quenched with water (30 ml). The resulting mixture was concentrated under vacuum to approximately 40 ml. The resulting suspension was stirred vigorously at room temperature for 1 h and the solids were collected by filtration and driedin a vacuum to give compound 47.2 (7.20 g, 88%) as a colourless solid. 1H NMR (ODd3,400 MHz) O 2.33 (t, 1H), 4.73 (d, 2H), 7.88 (d, 1H), 8.26 (d, 1H). LCMS (221.9 [M+H]).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137628-17-2, 2,3-Dibromo-5-chloropyridine.
Reference:
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
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