Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 717843-48-6, name is 3-Bromo-6-methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H5BrN2
Example 176 (7bR,11aS)-N-(2-Cyano-6-methyl-3-pyridinyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-6-amine, bis hydrochloride salt A solution of tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from Example 56, Part B (300 mg, 0.89 mmol), 2-cyano-3-bromo-6-methylpyridine (200 mg, 1.02 mmol) and cesium carbonate (565 mg, 1.73 mmol) in anhydrous toluene (10 mL) was stirred under an argon atmosphere in a sealable test tube. The mixture was degassed with argon. [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane (35 mg, 0.043 mmol) was added and the reaction was sealed and heated at 160 C. in a microwave oven for 3600 sec. The reaction mixture was cooled, filtered through a pad of silica gel and concentrated in vacuo. Purification of the residue by flash column chromatography (silica gel, 10-50% EtOAc/hexanes) provided tert-butyl (7bR,11aS)-6-(2-cyano-6-methyl-3-pyridinyl)-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate.
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Reference:
Patent; Robichaud, Albert J.; Fevig, John M.; Mitchell, Ian S.; Lee, Taekyu; Chen, Wenting; Cacciola, Joseph; US2004/186094; (2004); A1;,
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