Reference of 1335210-23-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1335210-23-5, name is 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid, molecular formula is C13H17NO8, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 1 (20.0 g, 63.4 mmol) and dichloromethane (150 mL) were added to the reaction flask, and the mixture was dissolved by stirring at room temperature. The temperature was lowered to 15-20 C, N, N-carbonyldiimidazole (13.9 g, 85.7 mmol) was added, and the reaction was kept under nitrogen protection for 2 hours. Compound 2 (10.0 g, 69.9 mmol) was added dropwise, and the temperature was raised to room temperature and reacted for 2 hours. The reaction solution was washed with a 1N aqueous HCl solution (100 mL), a 5% aqueous sodium carbonate solution (130 mL), and a saturated saline solution (100 mL) in this order. The organic phase was concentrated to dryness, and the obtained oil was separated by column chromatography [mobile phase: n-hexane: ethyl acetate (2: 1)] to obtain a white solid powder product compound 3 (18.9 g, 68%)
According to the analysis of related databases, 1335210-23-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Anhui Baker Bio-pharmaceutical Co., Ltd.; Wang Zhibang; Xu Jingkun; Tian Lei; Zhang Zuliang; Liao Jiehai; Zou Hui; Wang Yao; Liu Yang; (20 pag.)CN110655517; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem