In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117007-52-0, name is 3-Iodo-1H-pyrazolo[3,4-b]pyridine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives
i-PrMgCl (0.32 mL, 0.64 mmol) was added to 3-iodo-lH- pyrazolo[3,4-b]pyridine (3.1 mL, 0.61 mmol) in THF (3 mL) at O0C. After 10 minutes, another portion of i-PrMgCl (0.32 mL, 0.64 mmol) was added. After 10 minutes, neat cyclopropanecarbaldehyde (0.074 mL, 0.98 mmol) was added dropwise and stirred at O0C for 1 hour. The mixture was diluted with EtOAc (5 mL) and aqueous ammonium chloride, and extracted with EtOAc (2 X 5 mL). The resulting residue was purified via flash chromatography eluting with EtOAc to afford cyclopropyl(l H-pyrazolo [3, 4-b]pyridin-3- yl)methanol (0.052 g, 0.28 mmol, 44.9% yield).
The synthetic route of 117007-52-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; AHRENDT, Kateri A.; BUCKMELTER, Alexandre J.; DE MEESE, Jason; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen R.; LUNGHOFER, Paul; MORENO, David; NEWHOUSE, Brad; REN, Li; SEO, Jeongbeob; TIAN, Hongqi; WENGLOWSKY, Steven Mark; FENG, Bainian; GUNZNER, Janet; MALESKY, Kim; MATHIEU, Simon; RUDOLPH, Joachim; WEN, Zhaoyang; YOUNG, Wendy B.; WO2009/111279; (2009); A1;,
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