Electric Literature of 109-04-6 , The common heterocyclic compound, 109-04-6, name is 2-Bromopyridine, molecular formula is C5H4BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of n-BuLi (15.00 mmol) in diethyl ether (30.0 mL) at78 C was added dropwise to a solution of bromopyridine(15.00 mmol) in diethyl ether (25.0 mL). The resulting solutionwasstirred at 78 C for 2 h. And then, the solution of Bu3SnCl orMe3SnCl (15.00 mmol) in THF (10.0 mL) was added dropwise andstirred at 78 C for another 3 h. The resulting deep-red solutionwas warmed to room temperature over night and a heavy precipitateformed. Hydrolysis was achieved with a saturated aqueoussolution of NH4Cl. Subsequent treatments (Et2O extraction, dryingon anhydrous Na2SO4, concentration and flash chromatography)afforded pure product.
The synthetic route of 109-04-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie; Tetrahedron; vol. 69; 2; (2013); p. 902 – 909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem