The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,3-Dichloro-5-(trifluoromethyl)pyridine
1.82 kg of 3-chloro-2-chloro-5-trifluoromethylpyridine was dissolved in 27.231 L of methanol,Then 1.0119 kg of triethylamine was added thereto,Heated to reflux for 4 hours, and cooled to 20 C to obtain a reaction solution,The resulting reaction solution was filtered to obtain a filter cake,The resulting filter cake was vacuum dried at 40 C for 1 hour to obtain an organic salt; The organic salt obtained in step (1), 0.27 kg of hydrocyanic acid was added to 2.7 L of dichloromethane and 1.35 L of water,The reaction was stirred at 0 C for 3 hours to obtain a mixed solution, and the resulting mixture was allowed to stand at room temperature to obtain an organic phase a;The obtained organic phase a is added to hydrochloric acid to adjust its pH to 2 and then the layers are separated to obtain an acid water layer and an organic layer,The resulting organic layer was washed with water to a pH of 6 to give the washed water and the organic phase b; The organic phase b obtained in step is distilled at atmospheric pressure to 60 C and then distilled under reduced pressure,Collection of vacuum 2mmHg,The temperature of the ketone temperature of 70 to 120 C is 1.77 kg of 3-chloro-2-cyano-5-trifluoromethylpyridine,Yield 85.7%.
With the rapid development of chemical substances, we look forward to future research findings about 69045-84-7.
Reference:
Patent; Shandong Province Union Pesticide Industry Co., Ltd; Tang, Jianfeng; Pan, Guangmin; Li, Wenhong; Su, Jingchi; Zhao, Baoxiu; Liu, Jie; (9 pag.)CN106349159; (2017); A;,
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