Reference of 24484-93-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24484-93-3, name is Methyl 4-chloropicolinate. A new synthetic method of this compound is introduced below.
[0136] Into a three-necked bottom flask with tetrahydrofuran (250 mL), methyl 4-chloro-2-picolinate (50 g, 291 mmol, 1 eq) was added. N-(methyl-d3)amine hydrochloride (31 g, 437 mmol, 1.5 eq), anhydrous potassium carbonate (80 g, 583 mmol, 2 eq) were added with stirring. After the mixture was stirred at room temperature for 20 h, water (250 mL) and methyl tert-butyl ether (150 mL) were added. The mixture was stirred and separated to obtain the organic phase. The aqueous layer was extracted with methyl tert-butyl ether (100 mL). The organic phases were combined, dried over anhydrous sodium sulfate and filtered. The solvent in the filtrate was removed under reduced pressure to give the title compound (48 g, purity 99%, yield 96%) as a light yellow oily liquid. [0137] 1H NMR (DMSO-d6, 400 MHz): delta7.64 (dd, J=2 Hz, 5.2 Hz, 1H), 7.97 (d, J=1.6 Hz, 1H), 8.54 (d, J=5.2 Hz, 1H), 8.74 (br, 1H). [0138] MS (ESI, m/z) calcd. for C7H4D3ClN2O: 173, found: 174 [M+H]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24484-93-3, its application will become more common.
Reference:
Patent; SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD; Feng, Weidong; Gao, Xiaoyong; Dai, Xiaojun; US2013/60043; (2013); A1;,
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