In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 800401-67-6, name is Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, the common compound, a new synthetic route is introduced below. Quality Control of Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
To a solution of 2-(thietan-3-yl)ethanol (200 mg, 1.69 mmol), tris(butyl)phosphine (6.84g, 10% in hexane, 3.38 mmol) and 1 , l ‘-(azodicarbonyl)dipiperidine (860 mg, 3.38 mmol) in anhydrous tetrahydrofuran (20 mL) was added ethyl 5-chloro-lH-pyrrolo[2,3-c]pyridine-2- carboxylate (380 mg, 1.69 mmol) under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 3 hours. The resulting mixture was then concentrated in vacuo. The residue was purified by flash column (gradient eluting with 0 – 25% ethyl acetate in petroleum ether) to afford 400 mg of ethyl 5-chloro-l-[2-(thietan-3-yl)ethyl]-lH-pyrrolo[2,3-c]pyridine-2- carboxylate as a white solid.
The synthetic route of 800401-67-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; GAO, Lu; GUO, Lei; HUANG, Mengwei; LIANG, Chungen; WANG, Baoxia; WANG, Lisha; WU, Guolong; YUN, Hongying; ZHANG, Weixing; ZHENG, Xiufang; ZHU, Wei; WO2014/184163; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem