Adding a certain compound to certain chemical reactions, such as: 69950-65-8, Methyl 6-formyl-2-pyridinecarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 69950-65-8, blongs to pyridine-derivatives compound. Product Details of 69950-65-8
Methyl 6-[hydroxy[6-methoxy-2-phenyl-7-(trimethylsilyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridi ne-2-carboxylate n-Butyllithium (0.5 mL, a 2.6 mol/L n-hexane solution) was added to a tetrahydrofuran solution (2.8 mL) of 3-bromo-6-methoxy-2-phenyl-7-(trimethylsilyl)pyrazolo[1,5-a]pyridine (410 mg) at -78C under an argon atmosphere, and then the mixture was stirred at -78C for 30 minutes. A tetrahydrofuran solution (2.8 mL) of methyl 6-formylpyridine-2-carboxylate (360 mg) was added to the obtained mixture at -78C, and then the mixture was stirred at room temperature for 1 hour. A saturated ammonium chloride aqueous solution was added to the reaction mixture and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline and dried over anhydrous magnesium sulfate. The solvent was evaporated and then the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 4:1) to obtain a title compound as yellow liquid (303 mg). 1H-NMR (400 MHz, CDCl3) delta 0.53 (9H, s), 3.77 (3H, s), 4.07 (3H, s), 5.35 (1H, d, J = 2.4 Hz), 6.31 (1H, d, J = 2.4 Hz), 6.87 (1H, d, J = 9.7 Hz), 7.04 (1H, d, J = 9.7 Hz), 7.28 (1H, d, J = 7.9 Hz), 7.40 (1H, tt, J = 7.9, 1.8 Hz), 7.47 (2H, t, J = 7.9 Hz), 7.72 (1H, t, J = 7.9 Hz), 7.87-7.91 (2H, m), 8.04 (1H, d, J = 7.9 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,69950-65-8, Methyl 6-formyl-2-pyridinecarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; Kissei Pharmaceutical Co., Ltd.; SETO, Shigeki; UMEI, Kentaro; NISHIGAYA, Yosuke; TANIOKA, Asao; KONDO, Tatsuhiro; KONDO, Atsushi; TATANI, Kazuya; KAWAMURA, Naohiro; EP2669285; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem