As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 6-Oxo-1,6-dihydropyridine-3-carbaldehyde
A solution of 6-hydroxynicotinaldehyde SM 1(192mg, 4 mmol) and (S)-1-cyclopropylethanamine (170 mg, 2 mmol) in DCM (5 mL) and EtOH (5 mL) was added NaBH3CN(620 mg, 10 mmol), then stirred at RT for 16 h. The resulting reaction mixture was quenched withwater and extracted with DCM, dried and evaporated, purified by combiflash (methanol:DCM =1:20) to give compound 1(300mg, 78%). LC-MS: m/z = 193.1 [M+H]
With the rapid development of chemical substances, we look forward to future research findings about 106984-91-2.
Reference:
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem