Application of 109-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.
Synthesis of pyridin-2-yl-hydrazine (2): To a stirredsolution of 1 (20 g, 0.176 mol, 1 equiv) in hydrazine hydrate (200 mL, 10 vol) was stirred at 100 C for 48 h. When TLC (8:2 EtOAc and methanol) showed complete consumption of the starting material, the reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (5 × 500 mL), dried over Na2SO4 evaporated to dryness under reduced pressure to afford 2 (15.0 g, 78 %) as a red oil; 1H NMR (300 MHz,CDCl3): delta 8.14 (1H, d, J = 3 Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H,brs, -NH2); LCMS calculated for C5H7N3: 109.13; Found 110.1,[M+H]+
The chemical industry reduces the impact on the environment during synthesis 109-09-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Gandikota, N. Murthy; Bolla, R. Sekhar; Viswanath, I. V. Kasi; Bethi, Sridharreddy; Asian Journal of Chemistry; vol. 29; 9; (2017); p. 1920 – 1924;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem