As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58530-50-0, name is 2-(Pyridin-2-yloxy)acetic acid, molecular formula is C7H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 58530-50-0
5-(4-Aminophenyl)-1H-naphtho[1,2-e][1,4]diazepin-2(3H)-one (82 mg, 0.531 mmol) obtained in Example 1, (1), 2-(pyridyl-2-yloxy)acetic acid (47 mg, 0.314 mmol), HATU (302 mg, 0.795 mmol), diisopropylethylamine (138 mg, 1.06 mmol), and dimethylformamide (10 mL) were mixed, and the mixture was stirred at room temperature for 16 hours under a nitrogen atmosphere. To the reaction mixture, saturated aqueous sodium hydrogencarbonate was added, and the resulting mixture was extracted with ethyl acetate. Purification was performed in a conventional manner to obtain the title compound (25 mg, yield 21%) as white solid. 1 H NMR (DMSO-d6, 400 MHz) delta: 3.76 (1H, d, J=10Hz), 4.55 (1H, d, J=10Hz), 4.95 (2H, s), 6.9-7.0 (2H, m), 7.29 (1H, d, J=9Hz), 7.51 (2H, d, J=8Hz), 7.6-7.7 (6H, m), 8.01 (1H, br s), 8.14 (1H, d, J=4Hz), 8.39 (1H, br s), 10.34 (1H, br s), 10.83 (1H, br s)
With the rapid development of chemical substances, we look forward to future research findings about 58530-50-0.
Reference:
Patent; Nippon Chemiphar Co., Ltd.; Kyushu University; SAKUMA, Shogo; KOBAYASHI, Kunio; USHIODA, Masatoshi; IMAI, Toshiyasu; INOUE, Kazuhide; (36 pag.)EP3020707; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem