Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55279-29-3, name is 3-Aminoisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Aminoisonicotinaldehyde
tert-Butyl 4-({4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl)piperazine-1-carboxylate 3-Amino-pyridine-4-carbaldehyde (584 mg, 4.78 mmol) was dissolved in DCM (10 mL) and tert-butyl 4-(morpholin-2-ylmethyl)piperazine-1-carboxylate (1.50 g, 5.26 mmol) and NaBH(OAc)3 (1.11 g, 5.26 mmol) were added. The reaction mixture was heated in a microwave at 60 C. for 2.5 min, diluted with DCM (20 mL) and quenched with sat aq Na2CO3 (10 mL). The organic fraction was washed with sat aq NH4Cl (10 mL). The combined aq fractions were extracted with DCM (2*20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound as a yellow gum (2.46 g). LCMS (ES+): 392.1 [MH]+.
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Reference:
Patent; PROXIMAGEN LIMITED; Carley, Allison; Simpson, Iain; US2014/275063; (2014); A1;,
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