The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5315-25-3, name is 2-Bromo-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H6BrN
At room temperature, m-chloroperbenzoic acid (82 g, 475 mmol) was added to a solution of 2-bromo-6-methylpyridine 28 (40 g, 232.5 mmol) in chloroform (400 mL). The mixture was heated at 65 C. for 20 h and then was cooled to 0 C. for 3 h. After filtration of the precipitate, the filtrate was concentrated under reduced pressure. An aqueous solution of sodium hydroxide 2 M (100 mL) was added to this residue and this solution was extracted with dichloromethane (4×100 mL). The organic phases were combined, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give compound 29 in the form of a yellow solid, which was used in the rest of the synthesis without additional purification (35.48 g, 81%). M.p.: 48-55 C. 1H NMR (400 MHz, CDCl3) delta: 7.55 (dd, J=7.9; 1.6 Hz, 1H), 7.23 (dd, J=7.9; 1.6 Hz, 1H), 7.01 (t, J=7.9 Hz, 1H), 2.57 (s, 3H); 13C NMR (100 MHz, CDCl3) delta: 151.2, 133.5, 128.7, 125.3, 125.2, 19.3. HRMS (ESI+) calculated for C6H7NOBr [M+H]+, m/z 187.9711. found: 187.9698. Rf=0.33 (silica, dichloromethane-methanol 96:4).
With the rapid development of chemical substances, we look forward to future research findings about 5315-25-3.
Reference:
Patent; CISBIO BIOASSAYS; LAMARQUE, Laurent; PARKER, David; BUTLER, Stephen J.; DELBIANCO, Martina; US2015/361116; (2015); A1;,
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