Adding a certain compound to certain chemical reactions, such as: 462-08-8, Pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: Pyridin-3-amine
To a solution of pyridin-3 -amine (2.5 g, 26.3 mmol) in anhydrous tetrahydiOfuran (80 mL) was added 1 M sodium bis(trimethylsilyl)amide in tetrahydrofuran (52.6 mL, 52.6 mmol) in a steady stream. The mixture was stirred for 30 minutes, treated dropwise with a solution of di-feri-butyl dicarbonate (5.92 g, 26.3 mmol) in anhydrous tetrahydrofuran (20 mL), stirred for 3 hours and concentrated. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium chloride, dried over anhydrous MgSCu, filtered, and concentrated by rotary evaporation. Purification by chromatography on silica eluting with 3%> methanol in dichloromethane afforded an amber semisolid. The material was dissolved in ethyl acetate, treated with decolorizing charcoal and vacuum filtered through diatomaceous earth. Concentration of the filtrate by rotary evaporation afforded the title compound as a light gold solid (4.35 g, 85%). MS (DCI+) m/z 195 (M+H)+.
The synthetic route of 462-08-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH & CO.KG; MARING, Clarence J.; PRATT, John K.; CARROLL, William A.; LIU, Dachun; BETEBENNER, David A.; HUTCHINSON, Douglas K.; TUFANO, Michael D.; ROCKWAY, Todd W.; SCHOEN, Uwe; PAHL, Axel; WITTE, Adreas; WO2012/87833; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem