Reference of 1122-71-0 ,Some common heterocyclic compound, 1122-71-0, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of N3-methyl-N5-(( 15, 25)-2-methylcyclopropyl)-2-oxo- 1,2-dihydropyridine-3,5-dicarboxamide (42.8 mg, 0.17 mmol), (6-methylpyridin-2-yl)methanol (26.9 mg, 0.22 mmolcommercially available from, for example, Sigma-Aldrich) and 2- (tributylphosphoranylidene)acetonitrile (0.090 mL, 0.34 mmol; commercially available from, for example, TCI) in toluene (1 mL) in a sealed vial was heated at 100 C for 0.5 h in a microwave reactor. The volatiles were evaporated from the mixture under a stream of nitrogen and the residuewas redissolved in 3:1 methanol/DMSO (2 mL) and was purified by MDAP (2 x 1 mL injection, formic). The required fractions from both injections were combined, evaporated and dried in vacuo to give a dark brown oily residue. The residue was redissolved in 3:1 methanol/DMSO (1 mL) and was further purified by MDAP (1 x 1 mL injection, formic). The required fractions were combined, evaporated and dried in vacuo to give a pale yellow glass; N3-methyl-N5-((15,25)-2-methylcyclopropyl)-1-((6-methylpyridin-2-yl)methyl)-2-oxo- 1, 2-d ihydropyrid ine-3,5-d icarboxamide (42.2 mg, 0.12 mmol, 69 % yield).LCMS (2 mm formic) Rt = 0.63 mi m/z= 355 for [MH]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-71-0, 6-Methyl-2-pyridinemethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem