Application of 1594-58-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-58-7, name is N-Hydroxynicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.
3-(3-(pyridin-3-yl)-1 ,2,4-oxadiazol-5-yl)benzonithle 3-Pyridylamideoxime (Aldrich, 5.5 g, 40 mmol) was dissolved in 60 mL of pyridine and 3-cyanobenzoyl chloride (Aldrich, 6.6 g, 40 mmol) was added. The reaction mixture was heated to reflux for 4 hours and then cooled to room temperature. The solution was poured into water (500 mL), filtered, and the solid were collected and dried under vacuum. ^ H NMR (300 MHz, methanol- d4) delta ppm 7.87 (td, J=8.0, 0.7 Hz, 1 H), 8.10 (dt, J=8.1 , 1.4 Hz, 1 H), 8.23 (ddd, J=8.1 , 5.6, 0.8 Hz, 1 H), 8.56 (ddd, J=8.0, 1.7, 1.2 Hz, 1 H), 8.64 (td, J=1 .7, 0.7 Hz, 1 H), 9.04 (dd, J=5.4, 1 .0 Hz, 1 H), 9.23 (dt, J=8.1 , 1 .7 Hz, 1 H), 9.57 (d, J=1.7 Hz, 1 H); MS (+ESI) m/z 249 (M+H)+.
Statistics shows that 1594-58-7 is playing an increasingly important role. we look forward to future research findings about N-Hydroxynicotinimidamide.
Reference:
Patent; ABBOTT LABORATORIES; WO2008/73942; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem