As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1594-58-7, name is N-Hydroxynicotinimidamide, molecular formula is C6H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of N-Hydroxynicotinimidamide
Add 0.05 mol (6.85 g) to a 250 mL three-necked flaskN-hydroxynicotinamide,100mL acetonitrile as solvent,0.055 mol (5.5 g) of triethylamine as an acid binding agent, and stirring, 0.05 mol (16.5 g) of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride Diluted with 50 mL of ethyl acetate and added dropwise to the reaction flask.The reaction was carried out for 2 h after the completion of the dropwise addition.TLC monitoring until the reaction is complete,Add an appropriate amount of saturated sodium bicarbonate solution,Filtering,Made a brown solid,Rinse with methanol to obtain 18.1 g of a yellow solid.The yield was 96.02%.
With the rapid development of chemical substances, we look forward to future research findings about 1594-58-7.
Reference:
Patent; Qingdao University of Science and Technology; Wang Minghui; Xu Liangzhong; Liu Liancai; Sun Jianxin; Cui Huanqi; (7 pag.)CN109336879; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem