In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 271-63-6 as follows., 271-63-6
A solution of 1H-pyrrolo[2,3-b]pyridine (1.0 g, 1 equiv.) in DMF (30 mL) at 0 C wastreated portionwise with NB S (1.51 g, 1 equiv.) under argon, and the resulting solution wasstirred at 0 C for 20 mm. The reaction mixture was allowed to warm to RT and stirring was continued for 10 mm. Then, the reaction mixture was transferred to a separatory funnel containing distilled water, and extracted with EtOAc (2×150 mL). Combined organic extracts were dried over Na2SO4, were filtered, and the solvent was removed invacuo. The crude product was recrystallized from DCM to afford the expected product (1.55 g). LCMS: IVIW (calc?d): 197.0; MS (ES, m/z): 197.3, 199.3 [M+H].
The chemical industry reduces the impact on the environment during synthesis 271-63-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; E-THERAPEUTICS PLC; KOLUND?IC, Filip; MILEK, Mateja; POLJAK, Tanja; RO?CIC, Maja; STUBBERFIELD, Colin; VADLAMUDI, Srinivasamurthy; (139 pag.)WO2019/43373; (2019); A1;,
Pyridine – Wikipedia,
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