Adding some certain compound to certain chemical reactions, such as: 97483-77-7, name is 5-Bromopicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97483-77-7. 97483-77-7
5-(piperidin-1-yl)picolinonitrile A solution of 500 mg (2.73 mmol) 5-bromopicolinonitrile, 63 mg (0.07 mmol) Pd2 dba3 and 130 mg (0.27 mmol) 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl in 20 ml DME was stirred and degassed with N2 for 10 min. 1.45 g (6.83 mmol) K3PO4 and 297 mul (3.0 mmol) piperidine were added. The mixture was heated at 80 C. under N2 over night. The mixture was cooled to r.t. and filtered through a plug of SiO2 with CH2Cl2/MeOH 9:1. The filtrate was concentrated and purified by flash chromatography (SiO2, Pet. ether/EtOAc 4:1?1:1) to afford 323 mg (63%, yellow oil). 1H NMR (CDCl3) delta 8.28 (d, 1H), 7.47 (d, 1H), 7.05 (m, 1H), 3.37 (m, 4H), 1.69 (m, 6H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 97483-77-7.
Reference:
Patent; RESPIRATORIUS AB; US2012/40942; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem