In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; MOLECULAR-MECHANISMS; CINNAMALDEHYDE; DESIGN; REACTIVITY; INHIBITORS; TOXICITY in [Omar, Abdelsattar M.; El-Araby, Moustafa E.; Malebari, Azizah M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia; [Omar, Abdelsattar M.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11884, Egypt; [Abdelghany, Tamer M.; Abdel-Bakky, Mohamed S.] Al Azhar Univ, Fac Pharm, Dept Pharmacol, Cairo 11884, Egypt; [Safo, Martin K.; Ahmed, Mostafa H.] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA; [Safo, Martin K.; Ahmed, Mostafa H.] Virginia Commonwealth Univ, Inst Struct Biol Drug Discovery & Dev, Sch Pharm, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Virginia Commonwealth Univ, Dept Med, Div Hematol & Oncol, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Massey Canc Ctr, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Hunter Holmes McGuire VA Med Ctr, Richmond, VA 23249 USA; [Ahmed, Hany E. A.] Taibah Univ, Coll Pharm, Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 47114, Saudi Arabia; [Ahmed, Hany E. A.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo 11884, Egypt; [Elhaggar, Radwan S.] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11790, Egypt in 2020.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. HPLC of Formula: C6H5NO
Curcumin and trans-cinnamaldehyde are acrolein-based Michael acceptor compounds that are commonly found in domestic condiments, and known to cause cancer cell death via redox mechanisms. Based on the structural features of these compounds we designed and synthesized several 2-cinnamamido-N-substituted-cinnamamide (bis-cinnamamide) compounds. One of the derivatives, (Z)-2-[(E)-cinnamamido]-3-phenyl-N-propylacrylamide 8 showed a moderate antiproliferative potency (HCT-116 cell line inhibition of 32.0 mu M), no inhibition of normal cell lines C-166, and proven cellular activities leading to apoptosis. SAR studies led to more than 10-fold increase in activity. Our most promising compound, [(Z)-3-(1H-indol-3-yl)-N-propyl-2-[(E)-3-(thien-2-yl)propenamido) propenamide] 45 killed colon cancer cells at IC50 = 0.89 mu M (Caco-2), 2.85 mu M (HCT-116) and 1.65 mu M (HT -29), while exhibiting much weaker potency on C-166 and BHK normal cell lines (IC50 = 71 mu M and 77.6 mu M, respectively). Cellular studies towards identifying the compounds mechanism of cytotoxic activities revealed that apoptotic induction occurs in part as a result of oxidative stress. Importantly, the compounds showed inhibition of cancer stem cells that are critical for maintaining the potential for self-renewal and stemness. The results presented here show discovery of covalently acting Michael addition compounds that potently kill cancer cells by a defined mechanism, with prominent selectivity profile over non-cancerous cell lines.
HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Omar, AM; El-Araby, ME; Abdelghany, TM; Safo, MK; Ahmed, MH; Boothello, R; Patel, BB; Abdel-Bakky, MS; Malebari, AM; Ahmed, HEA; Elhaggar, RS or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem